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During purine synthesis why does GTP activate ad
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<p>1. Making "pre-energy" using the very energy needed is inefficient (but doable)</p> <p>2. You want to prevent interconversion of purines (solved by negative feedback)</p> <p>3. The intermediates in this pathway XXX known to XX XXXXX</p> <p>While there is definitely XXXXXXXX XXXXXXXX, in <strong>XXXX demand XXXXXX</strong> (pregnancy, hemolytic anemia, exercise, infection), you definitely XXX't XXXX <strong>toxic XXXXXXXXXXXXX</strong> to compound XXX XXXXXXXXX. XX'll XXXXX touch XX the XXXX complicated XX the two:GTP-dependentadenylosuccinate synthetase. XXXXXX likely prevents XXXXX XXXXXXXXXXXXX from XXXXXXXXXXXX. Of course,again, we XXX't XXXX XXX true "why," but XXX XXXX that GTPis XXXX in AMP/ATPproduction XXXXXXXXXXXXXXXXX the XXXXXX that the pathway's energy XXXXXXXXXXXX for production are XXXXXX XXX.</p> <p><strong>To look XX it another way</strong>, let's say you are XXXXXXX out XXX you use up a XXX XX XXX.XXX XXXX to XXXXXXXXX XXXX XXXXXXXXX, but the pathway requires ATPto make XXXXXXXXXX XXX (then ATP). XXX the dilemma?XXXXXXX, that's XXX XXX case XXXX, since XXXXXX be used in XXXX of XXX. XXX, XXX XXXXXXXXXXX is used XXX other functions, but XXXX XXXXXXX still XXXXXXX. You XXX XXXXX XX an exhaustive XXXXXX where XXXX of XXXXXXXXXXXX eats all your - say - XXX, so you XXXX XX replenish XXXX.</p> <p>As for why XXX is XXXXXX for XXX XXXXX XXXXXX, it's simply the most XXXXXXXX energy XXXXX in cells and XXX default one to XXX.</p> <p>Speaking of which, XXX<XXXXXX>committed step of this shared pathway</strong><strong> XX the XXXXXX XXXX via amidophosphoribosyl XXXXXXXXXXX</strong> (aka the ATP-XXXXXXXXX XXX). This means you have to XXX GMPor XXX at the XXX, or XXXX the XXXXXXXXXXXXX XXXX accumulate. If you have XXXXXXXXXXXX XXXXXX XX XXXXXXXX either XXXXXXX, XXXX can and XXXX cause toxicity. XX XXXXXXX of XXXXXXXXXX XXXX the committed step but not XXXXXXXXX is <XXXXXX>XXXXXXXX Intolerance (XX Fructosuria)</strong>.</p> <p><XXXXXX>Last, you are XXXXXXX: there XXX XXXX XXX regulatory points:</XXXXXX> XXXX synthetase, amidophosphoribosyl transferase, adenylosuccinate XXXXXXXXXX, and IMP dehydrogenase:</p> <p>1. GDPand XXX (synergistically)inhibitPPRP XXXXXXXXXX</p> <p>2. GMPand AMP XXXXXXX XXX amidophosphoribosyl XXXXXXXXXXX</p> <p>3. AMP XXXXXXXX the adenylosuccinate synthetase;XXXXXXXXXXX IMPdehydrogenase</p> <p>The only XXXXX XXXXXX XXXX XX left is looking at <strong>XXXXXX salvage pathways</XXXXXX> to appreciate further the regulatory XXXXX XX GTP/XXXXX <strong>purine interconversion XXXXXXXXXX</XXXXXX>.</p>">
